![]() Harvey M, Cave G (2007) Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Weinberg G, Di Gregorio G, Hiller D, Hewett A, Sirianni A (2009) Reversal of haloperidol-induced cardiac arrest by using lipid emulsion. Geib A-J, Liebelt E, Manini AF (2012) Clinical experience with intravenous lipid emulsion for drug-induced cardiovascular collapse. Eur Rev Med Pharmacol Sci 16(Suppl 1):38–42Ĭave G, Harvey M (2009) Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Taftachi F, Sanaei-Zadeh H, Sepehrian B, Zamani N (2012) Lipid emulsion improves Glasgow coma scale and decreases blood glucose level in the setting of acute non-local anesthetic drug poisoning-a randomized controlled trial. Haddad PM, Anderson IM (2002) Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Witchel HJ, Hancox JC, Nutt DJ (2003) Psychotropic drugs, cardiac arrhythmia, and sudden death. ![]() J Pharm Biomed Anal 20(6):889–898Īrinobu T, Hattori H, Iwai M, Ishii A, Kumazawa T, Suzuki O, Seno H (2002) Liquid chromatographic–mass spectrometric determination of haloperidol and its metabolites in human plasma and urine. Hempenius J, Steenvoorden R, Lagerwerf F, Wieling J, Jonkman J (1999) ‘High throughput’ solid-phase extraction technology and turbo ionspray LC-MS-MS applied to the determination of haloperidol in human plasma. Therefore, the proposed MISPE method could be applied in the extraction and preconcentration before HPLC-UV analysis of haloperidol in rabbit brain tissue. Finally, the imprinted polymer was successfully applied for the determination of haloperidol in a real rabbit brain sample after administration of a toxic dose. The MISPE method could effectively extract and concentrate haloperidol from brain tissue in the presence of clozapine and imipramine. Intraday precision and interday precision values for haloperidol analysis were less than 5.86 and 7.63 %, respectively. The limit of detection (LOD) and the limit of quantification (LOQ) of the assay were 0.008 and 0.05 ppm, respectively. The recovery of haloperidol in this MISPE process was calculated between 79.9 and 90.4 %. The extraction and analytical process was calibrated in the range of 0.05–10 ppm. Selectivity of the MISPE procedure was investigated using haloperidol and some structurally different drugs with similar polarity that could exist simultaneously in brain tissue. ![]() A molecularly imprinted solid-phase extraction (MISPE) method was developed for cleanup and preconcentration of haloperidol in brain samples before HPLC-UV analysis. An optimized MIP was selected and applied for selective extraction and analysis of haloperidol in rabbit brain tissue. Several molecularly imprinted polymers (MIPs) were prepared in the present work, and their binding properties were evaluated in comparison with a nonimprinted polymer (NIP).
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